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BioFlips logoThe BioFlips program demonstrated technologies for integrated biofluidic microprocessors capable of on-chip reconfiguration and self-calibration via feedback control. The prototypes developed in the program included on-chip sample-to-answer biological fluid assays for real-time monitoring of a soldier's health parameters. For DoD applications, complete "sample-to-answer" solutions in chip-scale devices are needed for robust, easy-to-use packages with minimum payload.

The BioFlips projects included four categories of deliverables: (1) front-end sample processing, (2) integrated detection architectures, (3) novel fluidic transport, and (4) integrated chip-scale applications. Projects developed platforms to tackle critical technical barriers of total integration. These platforms provided the chip designer the capability to lay out designs for integrated systems by simply connecting the components with predictable performance specifications. Compatible microfabrication technologies were developed to integrate multiple fluidic components (structures, sensors, and actuators), different materials, and different processes onto chip-scale devices. The program integrated on-chip fluidic transport components with sensors for dynamically controlled surface properties that enabled active chips by feedback control. These active chips are capable of reconfiguration and self-calibration.


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